More novel ideas

I thought I should get a few more ideas for my novel down, so that I have more to consult when the writer's block hits. First off, I was thinking that something in a Fallout-type setting might be interesting. Fallout is a post-apocalyptic role-playing game for the PC, where you are a person who grew up in an underground shelter and leaves for the first time in order to find a part that is needed to fix the water purification system and save the lives of everyone in the shelter. The game is very open ended, allowing at least two different ways to complete the game, including one in which you can play as a pacifist without ever killing anyone.
When I thought of this, I remembered this old idea I have had for the structure of a story that might be an effective defence against the writer's block. Essentially, I would radically change the setting every so often, a la Time Bandits. It might start in the real world, and then become a fantasy in the style of Tolkien, or at least in the style of Weis and Hickman. Next, it could become a space opera or my post-apocalyptic setting. I don't know what kind of plot would lend itself to this, but my main guide for writing this thing will be No Plot, No Problem, an handbook for novel writing in a month, writ en by the founder of National Novel Writing Month. Wish me luck!